Post cycle with Letrozole

Letrozole is mostly used as a strong protection from estrogenic side effects caused by a very long cycle of anabolic steroids.

Letrozole has been scientifically shown to have the ability to reduce estrogen levels in organs by up to 96-98%.


Letrozole is a third-generation nonsteroidal selective inhibitor. The structure and activity of this compound are very similar to that of Arimidex, and doctors prescribe it for similar medical reasons.

Specifically, in the United States Letrozole is prescribed for those women with postmenopausal treatments with estrogen receptors and positive receptor or estrogen and for breast cancer patients.

It is typically used as a second line of treatment after estrogen receptors like tamoxifen have failed to get a desirable response, although it is sometimes implemented as the first level of therapy depending on the circumstances.

Male bodybuilders and athletes find immense value in Letrozole for their ability to mitigate the estrogenic side effects associated with anabolic/androgenic steroid use, such as:

  • Gynecomastia
  • Fat buildup
  • Visible water retention

The FDA approved the sale with a prescription in the United States in 1997, with the official distribution pharmaceutical company Novartis, taking the Letrozole market under the brand name femara.

It is worth noting that the pharmaceutical company Novartis after FDA approval markets this drug in more than 70 nations around the world. The drug is usually delivered in doses of 2.5 mg.

Letrozole Benefits for Bodybuilders

In the field of bodybuilding Letrozole is widely used to protect high-performing athletes from estrogenic side effects caused by anabolic steroid administration.

Scientific studies conducted in 2011 and 2012 have shown that Letrozole has the effective ability to reduce the level of estrogen in users’ organs by up to 96-98%.

These percentages of effectiveness of the Letrozole compound are completely sufficient to obtain desirable results for steroid users. However, it has also been shown that Letrozole has the ability to significantly increase luteinizing hormone levels. This hormone is responsible for stimulating follicles, sex drive and globulin.

All this is unbeatable when all the attributes of Letrozole are combined with the fact that it is an ideal medicine for:

  • Protection against gynecomastia
  • Water retention

Aside from other estrogenic side effects, it is for this reason that Letrozole has become the favorite of many bodybuilders.

It is vitally important to note that, according to studies conducted by the University of Florida, where Letrozole was applied in animals, the results indicated that Letrozole helps reduce or even eliminate pre-existing gynecomastia.

Of course, as in all research there are limits, since these human studies have never been carried out.


Anecdotally some bodybuilders have claimed that they have experienced a reduction in the fat of their chest, but of course, these claims have their limitations not being carried out with due scientific controls.


It is tending approximately 60 days to get a constant level of Letrozole in the blood plasma once administration is started. This may require the user to start using Letrozole before starting their cycle, this in order for you to find yourself strong once you start your cycle.

You should be very careful as intake of Letrozole without medical supervision can hinder the compound’s ability to respond quickly.

This is usually done when the user initiates administration of the drug to counteract some side effects that have appeared.

Maximum dose

The maximum dose a user can use is 2.5 milligrams per day. It has been shown in numerous studies that this dosage will eliminate almost all estrogen in the body in almost all cases regardless of sex or age.

Any dose that is higher would simply be unnecessary. This is because despite Letrozole’s ability to increase levels of luteinizing hormone, follicle stimulating hormone, and sex hormone, if used during post-cycle globulin therapy can be counterproductive.

This is mainly due to the compound’s ability to catalyze estrogen levels too low during use. Once the compound is discontinued it can cause a rebound effect on estrogen levels that are quite high, something that should be avoided during or after post-cycle therapy.

Anastrozole is presented commercially as an alternative to Letrozole, but apparently does not have such a potent effect.

Finally, the detrimental effect that Letrozole has on the blood by altering lipid levels is another reason why many users avoid its use during post-cycle therapy.